The potential of glycomics as prognostic biomarkers in liver disease and liver transplantation
| Journal | Volume 82 - 2019 |
| Issue | Fasc.2 - Case series |
| Author(s) | X. Verhelst, A. Geerts, N. Callewaert, H. Van Vlierberghe |
| Full article |
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| (1) Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium ; (2) Center for Medical Biotechnology, VIB, Ghent, Belgium; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. |
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The study of glycomics is a novel and fascinating approach for the development of biomarkers. It has become clear that in the field of liver disease specific glycomic patters are present in specific disease states, which has led to the development of diagnostic biomarkers. In this manuscript, we will describe two new applications of this technology for the development of prognostic biomarkers. The first biomarker is associated with the risk of hepatocellular carcinoma development in patients with compensated cirrhosis. The second biomarker is present in perfusate and is related to the risk of primary non function occurrence after liver transplantation. The technology used for these biomarkers could easily be implemented on routine capillary electrophoresis equipment. (Acta gastroenterol. belg., 2019, 82, 309-313). |
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© Acta Gastro-Enterologica Belgica. PMID 31314193 |
